Title

Linking platelet indices and uterine artery Doppler parameters for preeclampsia prediction and its severity

Authors

Simran Verma^1,*, Shikha Singh², Nilam Bhasker³, Meenal Jain², Sangita Sahu⁴, Hari Singh⁵ & Navya Verma⁶

Affiliation

¹Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences Raebareli, Raebareli, Uttar Pradesh, India; ²Department of Obstetrics and Gynaecology, S.N. Medical College, Agra, Uttar Pradesh, India; ³Department of Pathology, ESIC Hospital, Lucknow, Uttar Pradesh, India; ⁴Department of Obstetrics and Gynaecology, S.N. Medical College, Agra, Uttar Pradesh, India; ⁵Department of Radiodiagnosis, S.N. Medical College, Agra, Uttar Pradesh, India; ⁶Modern School, Lucknow, Uttar Pradesh, India; *Corresponding author

Email

Simran Verma - E - mail: simranvrma1201@gmail.com
Shikha Singh - E - mail: drshikhasingh.shikha@gmail.com
Nilam Bhasker - E - mail: nilam2711@gmail.com
Meenal Jain - E - mail: drmeenalgyne@gmail.com
Sangita Sahu - E - mail: drsangitasahu@gmail.com
Hari Singh - E - mail: singhhariacademic@gmail.com
Navya Verma - E - mail: navya24verma@gmail.com

Article Type

Research Article

Date

Received December 1, 2024; Revised December 31, 2024; Accepted December 31, 2024, Published December 31, 2024

Abstract

Preeclampsia is one of the most common medical complications of pregnancy and the second largest cause of maternal and fetal mortality and morbidity. Preeclampsia is a multi-systemic hypertension condition with an unknown cause. A Prospective Observational Study was conducted on antenatal women with gestation age of 11 to 13+6 weeks. Participants underwent routine investigations including Platelet Indices and Uterine Artery USG Doppler. Selected patients were specifically evaluated at 22-24 weeks, 31-34 weeks, and >36 weeks until delivery along with routine antenatal care visits. Among the platelet indices, the platelet Count, Mean Platelet volume (MPV), Platelet/Lymphocyte ratio were found significant and among Uterine Artery Doppler Parameters- Pulsatility Index was found significant in prediction of preeclampsia. The Combination of platelet indices and uterine artery doppler parameters showed better sensitivity in prediction of early onset and severe form of preeclampsia can be incorporated into routine prenatal care using the existing infrastructure can be used in the prediction and early diagnosis of preeclampsia.

Keywords

Platelet count, mean platelet volume, platelet distribution width, plateletcrit, platelet/lymphocyte ratio, uterine artery pulsatility index, resistivity index, systolic/diastolic ratio, preeclampsia

Citation

Verma et al. Bioinformation 20(12): 1829-1833 (2024)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.