Title

A study on the effect of fibromyalgia severity on sleep quality using inflammatory markers

Authors

Ruchi Singh^1,*, Jyotsana Rai¹, Akash Pathak¹ & Nirendra kumar Rai²

Affiliation

¹Department of Physiology, AIIMS Bhopal, M.P, India; ²Department of Neurology, AIIMS Bhopal, M.P, India; *Corresponding author

Email

Ruchi Singh - E - mail: ruchi.physiology@aiimsbhopal.edu.in; Phone no: +91 7773010095

Jyotsana Rai - E - mail: jyotsana.jrf2021@aiimsbhopal.edu.in

Akash Pathak - E - mail: akashpathak134@gmail.com

Nirendra kumar Rai - E - mail: nirendrarai@gmail.com

Article Type

Research Article

Date

Received November 1, 2024; Revised November 30, 2024; Accepted November 30, 2024, Published November 30, 2024

Abstract

Fibromyalgia syndrome (FMS) is a widespread musculoskeletal pain, often accompanied by fatigue and sleep disturbances. Poor sleep exacerbates inflammation and pain, potentially increasing levels of inflammatory markers. This study explored the effect of FMS severity on CRP levels, sleep quality and pain intensity. 89 FMS individuals were explored for FMS severity, pain and sleep quality. CRP levels in blood and erythrocyte sedimentation rate (ESR) were measured to assess inflammation. An increase in FMS severity was associated with an increase in CRP and ESR levels, pain intensity and sleep disturbances. However, a positive correlation between CRP levels and sleep quality indicates that Poor sleep quality in FMS may contribute to elevated CRP levels. Addressing sleep quality may mitigate the severity of FMS and its associated symptoms.

Keywords

Fibromyalgia severity and pain intensity, fibromyalgia and C-reactive protein, sleep quality and fibromyalgia syndrome, fibromyalgia severity and inflammatory markers, sleep disturbances and inflammatory markers

Citation

Singh et al. Bioinformation 20(11): 1608-1612 (2024)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.