Title
Analysis of pH, electrolytes and non-invasive respiratory support in COPD with elevated CO2
Authors
Madeeha Hussaini1, Rida Minhaj2, Nukala Aishwarya3, Maanasa Kurapati4, Yazan Al Khatib5, Zehra Yousuf2, Mohamedelfatihmusaab Ibrahim Mohamed6, Rabia Azam7, Hamza A Orfali8 & Mohammed Abdul Mateen*, 1
Affiliation
1Shadan Institute of Medical Sciences, Teaching Hospital and Research Centre, Hyderabad, India; 2Deccan college of Medical Sciences, Hyderabad, India; 3Prathima Institute of Medical Sciences, Karimnagar, Telangana, India; 4Kamineni Institute of Medical Sciences, Narketpally, Telangana, India; 5Al Faisal University, Riyadh, Saudi Arabia; 6National Ribat University, Khartoum, Sudan; 7Quetta Institute of Medical Sciences, Quetta, Pakistan; 8Al Neelain University, Khartoum, Sudan; *Corresponding author
Madeeha Hussaini - E - mail: drmadeehahussaini@gmail.com
Rida Minhaj - E - mail: ridaminhaj@gmail.com
Nukala Aishwarya - E - mail: aishwaryareddy.nookala@gmail.com
Maanasa Kurapati - E - mail: maanasackurapati@gmail.com
Yazan Al Khatib - E - mail: yazanw2009.yak@gmail.com
Zehrayousuf - E - mail: zehrayousuf61@gmail.com
Mohamedelfatihmusaab Ibrahim Mohamed - E - mail: mohamedalfati7@gmail.com
Rabiaazam - E - mail: rabiakhan.839.rk@gmail.com
Hamza A Orfali - E - mail: dr.hamzaorfali@gmail.com
Mohammed Abdul Mateen - E - mail: mateenmohdabdul96@gmail.com
Article Type
Research Article
Date
Received October 1, 2024; Revised November 5, 2024; Accepted November 5, 2024, Published November 5, 2024
Abstract
The contributions of pH balance and electrolytes among patients with chronic obstructive pulmonary disease (COPD) experiencing hypercapnic exacerbations requiring non-invasive ventilation (NIV) are of interest. Hence, we used samples from 70 patients admitted in a tertiary care hospital from January to June 2023. The main variable analyzed was arterial blood gas data and serum electrolyte levels. A positive correlation between bicarbonate levels and PCO2 was found, with p < 0.01 and r = 0.74, indicating metabolic compensation for respiratory acidosis. NIV was required in the majority of patients: in 64.3%, values were higher for both PCO2 (52.3 ± 7.1 mmHg vs. 39.6 ± 4.3 mmHg) and bicarbonate levels (32.4 ± 4.8m Eq/L vs. 26.1 ± 3.1 m Eq/L; p < 0.01) in the NIV group. Thus, data highlights the role of monitoring PCO2 and bicarbonate in guiding the use of NIV and in a more secondary role to hypercapnia disturbances in electrolytes.
Keywords
Chronic obstructive pulmonary disease, hypercapnia, non-invasive ventilation, pH balance, electrolyte levels, arterial blood gas analysis, respiratory acidosis.
Citation
Hussaini et al. Bioinformation 20(11): 1503-1507 (2024)
Edited by
Reshma Parbeen
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
