Title
Geno-toxic risk assessment of locally produced bovine pericardium (LYOLEMB) for guided tissue regeneration
Authors
Abdo Mohammed Mohammed Abdulrazzaq1, Sultan Alanazi1,*, Ali M. Alyami2, Abdullah Awad Alshehri2, Turki Fahad Al Mansour2 & Yazeed Saleh AL-Ghwaynim2
Affiliation
1Department of Preventive Dental Science, Faculty of Dentistry, Najran University, Najran, Saudi Arabia; 2Faculty of Dentistry, Najran University, Najran, Saudi Arabia; *Corresponding author
Abdo Mohammed Mohammed Abdulrazzaq - E - mail: amabdulrazzaq@nu.edu.sa; Phone: +966 561855610
Sultan Alanazi - E - mail: smalanzi@nu.edu.sa; Phone: +966 504264536
Ali M. Alyami - E - mail: 437206028@nu.edu.sa; Phone: +966 509464240
Abdullah Awad Alshehri - E - mail: 438100549@nu.edu.sa; Phone: +966 556220697
Turki Fahad Al Mansour - E - mail: 437205988@nu.edu.sa; Phone: +966 500511075
Yazeed Saleh AL-Ghwaynim - E - mail: 438100284@nu.edu.sa; +966 53 551 0666
Article Type
Research Article
Date
Received October 1, 2024; Revised November 5, 2024; Accepted November 5, 2024, Published November 5, 2024
Abstract
This study evaluated the genotoxic risk of locally produced bovine pericardium (LYOLEMB) as a guided tissue regeneration (GTR) material for advanced periodontal disease using the Ames test with metabolic activation (a sodium phosphate buffer). Mutagenic effects on Salmonella typhimurium strains TA 98, TA 1537, TA 100, and TA 1535 at concentrations ranging from 0.3125 mg/plate to 5 mg/plate showed no significant genotoxicity, with revertant counts remaining below twice that of the control. Statistical significance was observed near p ≤ 0.05 at certain concentrations, confirming LYOLEMB's non-mutagenic, biocompatible and safe use in periodontal therapy.
Keywords
Ames test, LYOLEMB, safe, GTR, analysis
Citation
Abdulrazzaq et al. Bioinformation 20(11): 1489-1494 (2024)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
