Title
Effect of oral alpha lipoic acid in treatment of OSMF
Authors
AK Shafeem Khan1,*, Vikas Kulkarni1 & Abhay D. Havle2
Affiliation
1Department of ENT, Krishna Institute of Medical Sciences, Karad - 415110, Maharashtra, India; 2Department of Otorhinolaryngology, Krishna Institute of Medical Sciences, Karad - 415 539, Maharashtra, India; *Corresponding author
Shafeem Khan A.K - E - mail: shafeemkhan@gmail.com
Vikas Kulkarni - E - mail: vikasent@gmail.com
Abhay D. Havle - E - mail: abhayhavle@yahoo.co.in
Article Type
Research Article
Date
Received October 1, 2024; Revised October 31, 2024; Accepted October 31, 2024, Published October 31, 2024
Abstract
Oral submucous fibrosis (OSMF) is a potentially cancerous disorder that affects the oral mucosa and causes a range of symptoms. Therefore it is of interest to assessing the function of oral alpha lipoic acid as a therapy for OSMF is intriguing. Hence, fifty patients with OSMF symptoms were evaluated both before and after treatment. They were split into two groups: group A, which served as the control, received 1 ml steroid injection of thioacetamide and 1500 IU of hyaluronidase (HYAL) weekly along with the oral antioxidant α-lipoic acid for three months. Group B, which served as the case study, also received 3 months of steroid injection of thioacetamide and HYAL. Patients in group B were recalled for a clinical examination using a vernier caliper, and visual analog scale (VAS) and fibrous bands (FB) were assessed at the 1st, 3rd and 6th month. We found that controls had a comparable distribution pattern across visits when compared to the case. Treatment with alpha lipoic acid in conjunction with intralesional injection of thioacetamide and HYAL significantly reduced the severity of symptoms, especially burning sensation and mouth opening, in the case group over time, as previously determined.
Keywords
Alpha lipoic acid, oral submucous fibrosis, thioacetamide, vernier caliper, hyaluronidase
Citation
Khan et al. Bioinformation 20(10): 1401-1404 (2024)
Edited by
Neelam Goyal & Shruti Dabi
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
