Title

Validation of endothelin-1 and interleukin-1β as a biomarker for diagnosing peri-implant disorders

Authors

Pranav V Manek¹, Arpita Srivastava², Rahul Shrivastava³, Miloni Bhatt⁴, Naina Pattnaik⁵ & Manish Kumar^6,*

Affiliation

¹Department of Oral Medicine and Radiology, Pacific Dental College and Research Centre, Udaipur, Rajasthan, India; ²Department of Oral Medicine and Radiology, Government College of Dentistry Indore, M.P, India; ³Private Practitioner, Department of Prosthodontics, Revti Dental Clinic, Indore, MP, India; ⁴Department of Prosthodontics, Karnavati school of dentistry, Karnavati University, Gujarat, India; ⁵Department of Periodontics and Oral Implantology, Kalinga Institute of Dental Science, KIIT Deemed to be University Patia, Bhubaneswar, Odisha, India; ⁶Department of Dentistry, Dr. Laxminarayan Pandey Government Medical College & Hospital, Ratlam, M.P, India; *Corresponding author

Email

Pranav V Manek - E - mail: dr_pranav15@yahoo.co.in

Arpita Srivastava - E - mail: Khushi5s1@gmail.com

Rahul Shrivastava - E - mail: drrahulshri@gmail.com

Miloni Bhatt - E - mail: bhattmiloni.mb@gmail.com

Naina Pattnaik - E - mail: naina.pattnaik@kids.ac.in

Manish Kumar - E - mail: drmanishagarwalmds@gmail.com

Article Type

Research Article

Date

Received September 1, 2024; Revised September 30, 2024; Accepted September 30, 2024, Published September 30, 2024

Abstract

Endothelin-1 (ET-1) and interleukin-1β (IL-1β) is increased in periodontitis and is linked to inflammatory cytokines among other variables. The purpose of this study was to ascertain if ET-1 and IL-1β are utilized as an early indicator for peri-implant mucositis (PM) and peri-implantitis (PI), as well as to look into the relationship between ET-1 and IL-1β levels and peri-implant illnesses. 58 patients (30 males and 28 females) with a total of 152 implants were included for final analyses. Three groups were formed from the 152 qualifying implants. A plastic probe was used at low pressure of 0.25N to assess the peri-implant parameters like probing pocket depth (PPD), modified gingival index (mGI), BOP being present or absent and modified plaque index (mPI). Mean bone loss (MBL) and the average annual bone loss (ABL) were evaluated. The values were significantly greater in PI group and PM group as compared to healthy subjects. ET-1 and IL-1β levels are significantly increased in peri-implant illnesses. ET-1 and IL-1β may be utilized as diagnostic indicator for peri-implant disorders.

Keywords

Endothelin-1, biomarker, peri-implant mucositis & peri-implantitis

Citation

Manek et al. Bioinformation 20(9): 1148-1153 (2024)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.