Title

Antifungal effects of natural extracts on Candida albicans

Authors

Ami Rawal^1,*, Arpita Srivastava², Rahul Shrivastava³, Megha Goyal⁴, Angel Aghera⁵ & Naina Pattnaik⁶

Affiliation

¹Department of Oral Pathology and Microbiology, People's Dental Academy, Bhopal, M.P, India; ²Department of Oral Medicine and Radiology, Government College of Dentistry, Indore, M.P., India; ³Private Practitioner, Department of Prosthodontics, Revti Dental Clinic, Indore, M.P, India; ⁴Department of Oral Medicine and Radiology, MPCDRC, Gwalior, M.P, India; ⁵Department of Oral Medicine and Radiology, Ahmedabad Dental College and Hospital, Ahmedabad, Gujarat, India; ⁶Department of Periodontics and Oral Implantology, Kalinga Institute of Dental Science, Kiit Deemed to be University, Patia, Bhubaneswar, Odisha, India; *Corresponding author

Email

Ami Rawal - E - mail: amirawal16@gmail.com
Arpita Srivastava - E - mail: Khushi5s1@gmail.com
Rahul Shrivastava - E - mail: drrahulshri@gmail.com
Megha Goyal - E - mail: den_meghagoyal@yahoo.com
Angel Aghera - E - mail: angelagheramds@gmail.com
Naina Pattnaik - E - mail: naina.pattnaik@kids.ac.in

Article Type

Research Article

Date

Received September 1, 2024; Revised September 30, 2024; Accepted September 30, 2024, Published September 30, 2024

Abstract

Fungal infections caused by Candida albicans present significant challenges in clinical settings owing to rising resistance to conventional antifungal treatments. Natural products derived from medicinal plants, including tulsi (Ocimum sanctum), garlic (Allium sativum), cinnamon (Cinnamomum verum) and lemongrass (Cymbopogon citratus) are increasingly recognized for their potential antimicrobial properties and as alternative sources of antifungal therapies. This study evaluated the antifungal efficacy of Tulsi, Garlic, Cinnamon and Lemongrass extracts against Candida albicans using disk diffusion and broth microdilution methods. Natural extracts from Tulsi, Garlic, Cinnamon and Lemongrass demonstrated varying degrees of antifungal activity against Candida albicans. Tulsi emerged as the most effective, followed by garlic and cinnamon, whereas lemongrass showed comparatively lower efficacy. These findings underscore Tulsi's potential as a potent natural antifungal agent and warrant further exploration of its therapeutic applications in fungal infections.

Keywords

Tulsi, Garlic, Cinnamon, Lemongrass, Candida albicans, antifungal activity & medicinal plants.

Citation

Rawal et al. Bioinformation 20(9): 1142-1147 (2024)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.