Title
The lymphatic system: a pathway for meta-inflammation in permafrost immunity
Authors
Francesco Chiappelli1,2* and Lily Fotovat1
Affiliation
1Dental Group of Sherman Oaks, Sherman Oaks, CA 91403, 2UCLA Center for the Health Sciences, Los Angeles, CA 90095, *Corresponding author
Francesco Chiappelli - E-mail:Chiappelli.research@gmail.com
Lily Fotovat - E-mail: lilyfotovat@gmail.com
Article Type
Editorial
Date
Received September 1, 2023; Revised September 30, 2023; Accepted September 30, 2023, Published September 30, 2023
Abstract
The lymphatic system is the anatomical substratum of immunity. Lymphatics collect tissue exudates, which contain cell debris, peptides, micronutrients and pathogens, as well as immune naive and memory effector cells from the body tissues and organs into the lymph. Lined by endothelial cells cemented together by tight junctions to ensure their impermeability, lymphatics contain valves that prevent the backward flow of the lymph as it moves forward toward the right and left venous angles, the anatomical site of confluence with the venous blood. Meta-inflammation increases the permeability of lymphatics, rendering the elderly more susceptible to novel and ancient airborne viruses released by melting glaciers and permafrost. Simple public health protocols (e.g., mask-wearing, quarantine) are essential to minimize colliding epidemics/pandemics, and favor permafrost immunity.
Keywords
Lymphatics, pro-inflammatory cytokines, meta-inflammation, inflamm-aging, permafrost pathogens, pandemic, public health
Citation
Chiappelli and Fotovat, Bioinformation 19(9): 886-888 (2023)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
