Title
Gene expression analysis of alkaline phosphatase in peri-implantitis tissue
Authors
Saumya Mehta1, Subhashree Rohinikumar*1, Abhinav Rajendra Prabhu1, Thiyaneswaran Nesappan1, Vishnu Priya Veeraraghavan2 & Rajalakshmanan Eswaramoorthy*3
Affiliation
1Department of Implantology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India; 2Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India. 3Department of Biomaterials, Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Medical and Technical Sciences, Saveetha University, Chennai 600077, India; *Corresponding author
Saumya Mehta – E-mail: saumyamehta0027@gmail.com
Subhashree Rohinikumar – E-mail: subhashreer.sdc@saveetha.com
Abhinav Rajendra Prabhu – E-mail: trilokabhinav@gmail.com
Thiyaneswaran Nesappan – E-mail: dr.thiyan@gmail.com
Rajalakshmanan Eswaramoorthy – E-mail: rajalakshmanane.sdc@saveetha.com
Vishnu Priya Veeraraghavan – E-mail:vishnupriya@saveetha.com
Article Type
Research Article
Date
Received April 1, 2023; Revised April 30, 2023; Accepted April 30, 2023, Published April 30, 2023
Abstract
Peri-implantitis is a condition that causes inflammation and bone loss around dental implants. Alkaline phosphatase (ALP) is a gene involved in the inflammation of the tissue. Therefore, it is of interest to evaluate the expression of the ALP gene around the peri-implantitis site. 20 samples were collected and analyzed using qRT-PCR, and statistical analysis was performed. The results showed a significant decrease in ALP expression in infected peri-implantitis tissue compared to normal tissue, indicating that ALP gene is involved in the inflammation of peri-implantitis and correlates with clinical findings.
Keywords
Alkaline phosphatase, Peri-implantitis, Polymerase Chain Reaction, mineralization
Citation
Mehta et al. Bioinformation 19(4): 506-509 (2023)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
