Title
Molecular docking analysis of proflavin with the Wnt pathway targets for OSCC
Authors
Jayanthi Pazhani, Vishnu Priya Veeraraghavan & Selvaraj Jayaraman*
Affiliation
Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai-600077, India; *Corresponding author
Jayanthi Pazhani – E-mail: drjayanthip@gmail.com
Vishnu Priya Veeraraghavan – E-mail: vishnupriya@saveetha.com
Selvaraj Jayaraman – E-mail: selvarajj.sdc@saveetha.com
Article Type
Research Article
Date
Received April 1, 2023; Revised April 30, 2023; Accepted April 30, 2023, Published April 30, 2023
Abstract
Wnt signaling pathway plays a critical role in tumor progression and metastasis of various cancer types. Therefore, it is of interest to document the molecular docking analysis of proflavin with the Wnt pathway targets (GSK3β, β-catenin, and VIM) for oral squamous cell carcinoma (OSCC). These results suggest that targeting the wnt signaling downstream targets with proflavine might leads to the better outcome for therapeutic outcome for the inhibition of invasion and metastasis in oral squamous cell carcinoma.
Keywords
Oral carcinoma, wnt signaling, proflavine, molecular docking.
Citation
Pazhani et al. Bioinformation 19(4): 464-466 (2023)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
