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Micro RNA210 expression in pregnancies with preeclampsia



Shali Paremmal1, Nidhi Sharma2, Rama Devi3 & Keerti gopi4*



1Department of Anatomy, Government Medical College Mahabubnagar, Telangana; 2Department of obstetrics and gynaecology, Saveetha Medical College, Tamilnadu; 3Department of Microbiology, Government Medical College Mahabubnagar, Telangana; 4Department of Biochemistry, Government Medical College Mahabubnagar, Telangana; India: *Corresponding author.



Shali Paremmal - E-mail: shalip90@gmail.com

Nidhi Sharma - E-mail: drbonuramkumar@gmail.com

Rama Devi - E-mail: kollabathulla.rama@gmail.com

Keerti Gopi - E-mail: keerthi.gopi77@gmail.com


Article Type

Research Article



Received March 1, 2023; Revised March 31, 2023; Accepted March 31, 2023, Published March 31, 2023



Preeclampsia is one of the major causes of perinatal mortality and morbidity even in developed countries, the aetiology of which is not yet understood completely. In recent times, mi RNAs have gained prominence as regulators of the expressions of their target genes in health and pathological condition. mi RNA210, one of the important hypoxamirs, is reported to be a  regulator of many cellular mechanisms including cell division, differentiation, apoptosis, cell cycle regulation, mitochondrial function, metabolism etc. Since hypoxia is the microenvironment that prevailed in preeclampsia it is worth full to see the expression pattern of mi RNA 210 as an attempt to unearth the preeclampsia pathogenesis. The placental tissue is collected from age-matched control and preeclamptic patients after strictly applying the inclusion and exclusion criteria. The present result shows 2.7 fold-up regulation of miRNA210 in preeclampsia in rt PCR study, the role of which need to be studied further to understand the pathogenesis of preeclampsia.



Preeclampsia, hypoxia, microRNA 210



Paremmal et al. Bioinformation 19(3): 319-322 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.