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A review on bigonial width reduction by botulinum toxin injections in masseter



Anjali Sharad Ghatge1, Sharad Balasaheb Ghatge2,3 & Vini Mehta4,*



1Consultant Aesthetic Dermatogy, The Apollo Clinic, Mumbai 400001, India; 2Division of Interventional Radiology, Department Of Radiology and Imaging, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India; 3Department of Interventional Neuroradiology, Bombay Hospital, Mumbai, Maharashtra, India; 4Department of Public Health Dentistry, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune 411018, India; *Corresponding author



Vini Mehta - E-mail: vini.mehta@statsense.in

Anjali Sharad Ghatge: E-mail: dranjalighatge@yahoo.com

Sharad Balasaheb Ghatge: E-mail: drsharadghatge@yahoo.com


Article Type




Received March 1, 2023; Revised March 31, 2023; Accepted March 31, 2023, Published March 31, 2023



It is of interest to study the efficacy of botulinum toxin injection in masseter reducing bigonial width of the face. Online databases such as PubMed, Cochrane Library, Google Scholar, Science Direct database and ResearchGate were searched from initiation until October 2022 using keywords such as “masseter muscle injections”, “botulinum toxin,” “bigonial width reduction,” “masseter muscle hypertrophy,” and “lower face contouring” All available retrospective as well as prospective studies, were included with specific weightage to the efficiency of Botulinum Toxin (BT) injection in masseter muscle and the technique, unfavorable events, and the extent of its effects. A total of 20 publications were acknowledged. All prospective studies were included. Relevant data on patient selection, injection methods, efficiency, dose, rate of recurrence, and significant side effects of BT injections in masseters were collected. All excluding one were prospective studies. Bilateral injections were used in all the studies. Follow up period was 3-48 months. This systematic review focuses on the effectiveness of Botulinum toxin injection in lowering the bigonial width by decreasing the volume of the masseter. Repeat treatment at regular intervals is advisable to maintain desired results. The procedure was carried out in an office environment and was completed within 15 mins. There are no permanent adverse events related to the procedure. Further studies involving randomized control trials with larger sample sizes are warranted to optimize the dose and frequency of BT injection.



Masseter muscle injections, botulinum toxin injection, bigonial width reduction



Ghatge et al. Bioinformation 19(3): 272-277 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.