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A study of socio clinical, biochemical and electrocardiographic changes of yellow oleander seed poisoning in India



Murugan Subramani1, Mudali Anbarasan1, Shanmugam Deepalatha2, Lakshmi Narayanan Muthumani1,* & Mallu Azmeera Mahesh 1



1Department of General Medicine, K.A.P Viswanatham Govt Medical College, Trichy 17, India; 2Department of Microbiology, Thanjavur Medical College, Thanjavur; India; Communicated by P. Vijayalakshmi - pvijibi@gmail.com; *Corresponding author



Murugan Subramani- E-mail: drsubbu1976@gmail.com

Mudali Anbarasan - E-mail: anbarasanmudali@gmail.com

Shanmugam Deepalatha - E-mail: drdeepamani@gmail.com

Lakshmi Narayanan Muthumani - E-mail: drmuthumani@yahoo.co.in

Mahesh Azmeera - E-mail: mahesh.azmeera@gmail.com         

L. Muthumani E-mail: drmuthumani@yahoo.co.in


Article Type

Research Article



Received March 1, 2023; Revised March 31, 2023; Accepted March 31, 2023, Published March 31, 2023



Yellow oleander (Thevetia peruviana), which belongs to the Apocyanaceae family, is a common shrub seen throughout the tropics. All parts of the plant contain high concentrations of cardiac glycosides, which are toxic to cardiac muscle and the autonomic nervous system. The main objective of this study was to socio-clinical, biochemical and electrocardiographic changes of yellow oleander seed poisoning. This prospective observational study was conducted over a period of 6 months (March 2022 to September 2022). Oleander seed poison in most prevalent in the   2140 years age. More the crushed seeds consumed and the delay to admission to the hospital for treatment poorer was the outcome. The most common GI symptoms of yellow oleander poisoning were vomiting (58 %), abdominal pain (28%), diarrhoea (9%), and palpitations (20%), dizziness (18%).Serum potassium levels that were measured during the admission were directly related to the ECG changes. ECG changes were more observed with patients those who consumed seeds in crushed form and this difference is statistically significant (P = 0.0001). Higher incidence of cardiotoxicity was noted with patients those who consumed poison on empty stomach compare to who consumed after food. The Electrocardiographic manifestations was found even with consumption of one seed, number of seeds consumptions independent of cardiotoxicity.Additonally higher mean Potassium value observed in patients who had cardiotoxicity when compared to patient who had no cardiotoxicity. Death of the patients in yellow oleander seed poisoning was independent of quantity of the seeds they have ingested.



Thevetia peruviana, Toxicity, cardiotoxicity



Subramani et al. Bioinformation 19(3): 244-250 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.