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Phytochemical screening and anti-obesity, anti- diabetic and anti-oxidant properties of Scoparia dulcis leaf decoction (crude)



Arulandhu Clara Mary1, Christopher Ireen1,2,, PeriyasamyVijayalakshmi1,2, Sabapathy Indhu1,2,,  Sekar Divyabharathi 3,  Kulandaisamy Suregka Felix 4, Viyagulasamy Daisyrani5 & Manikkam Rajalakshmi1,2,3*



1Department of Biotechnology and Bioinformatics, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India; 2DBT-BIF Centre, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India; 3Department of Zoology, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India; 4Department of Business Administration, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India; 5Department of  Social Work, Holy Cross College (Autonomous), Tiruchirappalli, Tamil Nadu, India; *Corresponding author



A. Clara Mary E-mail: claramary@hcctrichy.ac.in

C. Ireen - E-mail:  ireen@hcctrichy.ac.in

P. Vijayalakshmi - E-mail: vijayalakshmi01@hcctrichy.ac.in

S. Indhu - E-mail: sabaindhu2010@gmail.com

S. Divyabharath - E-mail: mdrajimd@gmail.com

M. Suregka - E-mail: suregkafelix@hcctrichy.ac.in

V. Daisyrani - E-mail: daisyrani@hcctrichy.ac.in.

M. Rajalakshmi - E-mail: rajalakshmi@hcctrichy.ac.in & mdraji@gmail.com


Article Type

Research Article



Received March 1, 2023; Revised March 31, 2023; Accepted March 31, 2023, Published March 31, 2023



Due to their rising prevalence, diabetes and obesity were both classified as epidemics by the World Health Organization.The natural leaf essence of Scoparia dulcis (S. dulcis), is used as herbal remedy for diabetes and obesity worldwide. However, the objective of the current research was to examine the effects of consuming commercially available S. dulcis porridge on both diabetes and obesity. The S. dulcis plants were collected and the essence was prepared in a traditional way. Phytochemical screening was carried out to identify the secondary metabolites present in the essence. The GC-MS analysis was carried out to identify the bioactive compounds present in the extracts.  In order to understand the molecular interaction of identified compounds with selected target proteins from anti-diabetic, anti-oxidant, anti-obesity molecular docking studies was carried out. Results of this docking studies confirmed that identified compounds showed the strong interaction with all the selected target protein. Further experimental analysis is needed to confirm this activity.



Diabetes, Scoparia dulcis, phytocompounds & molecular docking.



     Clara Mary et al. Bioinformation 19(3): 238-243 (2023)


Edited by

P Kangueane






Biomedical Informatics



This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.