Title
Expression analysis of cyclin D, Ki-67, MCM3 and MCM2 in oral squamous cell carcinoma
Authors
Dushyantsinh Vala1*, Tarang Mehta2, Mahesh Arjun Gadakh3, Mimansha Patel4, Animesh Mondal5 & Bharti Gupta6
Affiliation
1Department of Oral and Maxillofacial Pathology and Oral Microbiology, Government Dental College and Hospital, Jamnagar, India; 2Department of Oral & Maxillofacial Pathology and Oral Microbiology, Narsinhbhai Patel Dental College & Hospital, Sankalchand Patel University, Gujarat, India; 3Department of Oral Pathology & Microbiology, SMBT Institute of Dental Sciences & Research., Dhamangaon, Nashik, India; 4Department of Oral Pathology and Microbiology, Triveni Dental College, Bodri, Bilaspur, Chhattisgarh, India; 5Department of Oral and Maxillofacial Pathology, Dr. R. Ahmed Dental College & Hospital, Kolkata, West Bengal, India; 6Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia;
Dushyantsinh Vala - E-mail: mr.d3ntist@gmail.com; Phone: +91 9429 558855
Tarang Mehta - E-mail:tarangmehta111@gmail.com; Phone: +91 8460384011
Mahesh Arjun Gadakh - E-mail:drmahesharjun@gmail.com; Phone: +91 8273789241
Mimansha Patel - E-mail:mimanshapatel_24@yahoo.com; Phone: +91 9516793530
Animesh Mondal - E-mail:animeshmondal106@gmail.com; Phone: +91 9038053964
Bharti Gupta - E-mail:drbhartigupta09@gmail.com; Phone: +96 6534639276
Article Type
Research Article
Date
Received December 1, 2023; Revised December 31, 2023; Accepted December 31, 2023, Published December 31, 2023
Abstract
The expression analysis of cyclin D1, Ki-67, MCM3 and MCM2 in oral squamous cell carcinoma to identify biomarkers is of interest. 45 formalin-fixed paraffin embedded tissue blocks collected from archives of Department of Oral and Maxillofacial Pathology and Oral Microbiology, Government Dental College and Hospital, Jamnagar, India were subjected to a retrospective cross-sectional immuno-histo-chemistry examination. 30 blocks of OSCC with histological diagnosis have 15 tissue blocks of well-differentiated oral carcinoma and 15 tissue blocks of moderately-differentiated oral carcinoma. 15 specimens of normal oral mucosa (NM) were also examined for comparison.
In each of the categories, the immuno-histo-chemistry expression of cyclin D1, MCM 3, MCM 2, and ki67 was studied. Data shows that cyclin D1, Ki-67, MCM3 and MCM2 effectively indicate cellular proliferation for consideration as potential biomarkers of oral squamous cell carcinoma.
Keywords
Cyclin D, mini-chromosome maintenance molecules, MCM3, MCM2 and Ki-67, oral squamous cell carcinoma
Citation
Vala et al. Bioinformation 19(13): 1405-1410 (2023)
Edited by
Vini Mehta & Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
