¹Department of Dentistry, Vijaynagar Institute of Medical Sciences, VIMS Campus, Cantonment, Ballari - 583104, India; ²Senior Resident, Department of Dentistry, SMS Medical College, Jaipur, India; ³Department of Oral Pathology, Microbiology and Forensic Odontology, Dental Institute, Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India; ⁴Periodontology Preventive Dental sciences Department College of Dentistry, Gulf Medical University, Ajman UAE; ⁵Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia; ⁶Oral and Maxillofacial Surgery, Department of Biomedical and Dental Sciences, Faculty of Dentistry, Al Baha University, Al Aqiq Campus, Kingdom of Saudi Arabia; ⁷Department of Oral medicine and Radiology, New Horizon Dental College and Research, Institute, Sakri, Bilaspur, Chhattisgarh, India; ⁸Department of Oral Medicine and Radiology, Narsinbhai Patel Dental college and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India;

Evaluation of immuno-histochemical (IHC) markers like p53, p63, PDPN, C-erb-B2, CK19, and VEGF in oral squamous cell carcinoma (OSCCs) is of interest to dentists. Sixty formalin-fixed paraffin embedded tissue blocks from the Department of Oral Pathology, New Horizon Dental College and Research, Institute, Sakri, Bilaspur, Chhattisgarh, India. The conventional IHC method was used to assess the expression of p53, p63, PDPN, C- erb-B2, CK19 and VEGF using the different antibodies. Data shows that P53, p63 had high values of labeling index (LI) of staining while PDPN, C-erb-B2 had low values of LI of staining. The values of LI of staining for CK19, and VEGF were in between the two types of IHCs. Combining the analysis of multiple IHC markers for OSCC can yield precise cancer diagnosis results.

Immunohistochemistry, markers, oral squamous cell carcinoma