Title
Linking D-Dimer and haematological parameters among Indian COVID 19 patients
Authors
Rashmi GS Basavaraj1,*, Ravikumar B Malladad2, Ashwini Ratnakar3 & Manasa Reddy4
Affiliation
1Department of Pathology, Haveri Institute of Medical Sciences, Haveri, Karnataka, India; 2Department of Emergency Medicine, Subbaiah Institute of Medical Sciences, Karnataka, India; 3Department of General Pathology, KAHER’s JNMC, Belagavi, Karnataka, India; 4Consultant Pathologist, Sri Padma Gastro Care Clinic, Karnataka, India;
Rashmi GS Basavaraj - E-mail: rashmimalladad@gmail.com & ganeshbabu370@gmail.com
Ravikumar B Malladad - E-mail: rbmalladad@gmail.com
Ashwini Ratnakar - E-mail: ashwininov5@gmail.com
Manasa Reddy - E-mail: drmanasareddy26@gmail.com
Article Type
Research Article
Date
Received December 1, 2023; Revised December 31, 2023; Accepted December 31, 2023, Published December 31, 2023
Abstract
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak continues to place a significant strain on healthcare systems, economies, and patient management. Therefore, it is of interest to evaluate the role of D-Dimer and haematological parameters to identify severity and outcome of COVID 19 patients. Total 100 cases diagnosed with COVID 19 were recruited in the study and followed up for 6 months. The subjects were grouped into 2, Group 1: Newly Diagnosed COVID 19 Patients and Group 2: After 6 months of follow up COVID 19 Patients. We analyzed Hb, RBCs, WBCs, PT, APTT and D-Dimer and also, we taken CT values of the study subjects. A statistical analysis was done by using SPSS version 20.0. The WBCs and haemoglobin mean values are shown significant values between the study subjects, respectively with p-values < 0.001**. The PT and APTT significantly increased in newly diagnosed COVID 19 patients when compared to after 6 months of follow up at p–value < 0.001**. There was a positive correlation of WBCs, PT, APTT (r= 0.458, 526, 509) with D-Dimer and negatively correlated RBCS, Hb, CT (-0.056, 321, 526, 353), respectively at p < 0.001**. Thus, low platelet, high d-dimer, and fibrinogen may serve as risk markers for the progression of COVID-19 severity. Hence, COVID-19 patients may experience anaemia-related consequences as hypoxia, coronary and pulmonary failure due to low Hb concentration. Further, patients with COVID-19 also experience bleeding issues due to thrombocytopenia.
Keywords
COVID-19, D-Dimer, CT and anaemia
Citation
Basavaraj et al. Bioinformation 19(12): 1179-1183 (2023)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
