Title

Effect of curcumin, betadine and chlorhexidine in gingival wound healing

Authors

Ankita Agrawal¹, Rashmi Kiran Ekka², Deepika Singla³*, Patiksha Kumar⁴, Deepak Kochar⁵, Ruhi Sidhu⁶, Bharat Gupta⁷ & Kapil Paiwal⁸

Affiliation

¹Department of Conservative and Endodontics, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India; ²Department of Oral Medicine and Radiology, Bhabha College of Dental Sciences, Bhopal, MP, India; ³Department of Conservative Dentistry & Endodontics, Desh Bhagat Dental College & Hospital, Mandi Gobindgarh, Punjab, India; ⁴Department of Oral Pathology & Microbiology, Government College of Dentistry, Indore, M.P., India; ⁵Department of Periodontology, M.M. College of Dental Sciences & Research, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India; ⁶Oral Medicine and Radiology, MNDAV Dental College and Hospital, Tatul, Oachghat, Solan, Himachal Pradesh, India; ⁷Department of Periodontics, MGM Dental College, Navi Mumbai, India;⁸Department of Oral & Maxillofacial Pathology, Daswani Dental College & Research Center, Kota, India

Email

Ankita Agrawal - E-mail:agrawalankita008@gmail.com; Phone: +91 9006284360

Rashmi Kiran Ekka - E-mail:drrashmi4876@gmail.com; Phone: +917024124076

Deepika Singla - E-mail:dsingla2810@gmail.com; Phone: +91 9888624200

Patiksha Kumar - E-mail:dr.pratiksha.kumar@gmail.com; Phone: +91 98262 77022

Deepak Kochar - E-mail:drdeepakkochar@mmumullana.org; Phone: +919991099901

Ruhi Sidhu - E-mail:ruhi.sidhu@yahoo.com; Phone: +91 98550 67639

Bharat Gupta - E-mail:guptabhar@gmail.com; Phone: +91 90299 75452

Kapil Paiwal - E-mail:drpaiwal@gmail.com; Phone: +91 80006 75259

Article Type

Research Article

Date

Received December 1, 2023; Revised December 31, 2023; Accepted December 31, 2023, Published December 31, 2023

The effect of chlorhexidine (CHX) digluconate, Betadine (BET), curcumin (CUR) on gingival wound healing is of interest to dental practitioners. Hence, we studied the average fibroblast viability % for each of the concentrations of CUR, BET and CHX over various time durations. It was found that mean percentage of viability of fibroblasts is high in CUR and low in CHX at all time periods while the mean percentage of viability of fibroblasts in BET 1% was greater than CHX but lower than CUR at all time periods. Thus, curcumin at a concentration of 0.003% demonstrates the least cytotoxicity for fibroblasts. Hence, it is the most effective bacterial suppression, and the best wound healing.

Keywords

Curcumin, chlorhexidine, human fibroblast viability, migration

Citation

Agrawal et al. Bioinformation 19(12): 1153-1158 (2023)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.