Title
Interleukin-6 and uric acid among type 2 diabetes mellitus patients with coronary artery disease
Authors
Gadigeppa H Chittaragi1*, Anand P Ambali2, Rajesh Honnutagi2 & Veluri Ganesh2
Affiliation
1Department of Medicine, Sri BM Patil Medical College Hospital and Research Centre, BLD & DU, Vijayapura, Karnataka, India & 2Department of Biochemistry, ESIC Medical College and Hospital, Kalaburagi, Karnataka, India
Gadigeppa H Chittaragi- E-mail: chittaragihospital@gmail.com
Anand P Ambali - E-mail:anandambal@bioedu.ac.in
Honnutagi - E-mail: drhoonatagi@gmail.com
Veluri Ganesh- E-mail : ganeshbabu370@gmail.com
Article Type
Research Article
Date
Received December 1, 2023; Revised December 31, 2023; Accepted December 31, 2023, Published December 31, 2023
Abstract
The type 2 diabetes mellitus is considering as metabolic disorder, the unfavourable long-term outcomes and closely associated with chronic inflammation. The present study investigated to explore the association of interleukin-6 and uric acid in patients with type 2 diabetes mellitus and coronary artery disease. Newly diagnosed CAD patients with T2DM (100) and T2DM and CAD patients after 5 years (100) underwent detailed anthropometric, demographic, biochemical and experimental characterization. The serum levels of interleukin 6 were measured by enzyme linked immuno-sorbent assay. The T2DM and CAD patients after 5 years had significant higher circulating levels of interleukin 6 and significant decreased levels of uric acid. The newly diagnosed CAD patients with T2DM had significant higher circulating levels of interleukin 6. Significant positive correlation was found between fat mass and IL-6, and negative correlation with uric acid and IL-6, (P<0.05). The both the groups of T2DM with CAD patients shown significantly elevated levels of interleukin 6, based on this findings interleukin 6 might be used as early predictable and prognostic marker for CAD in patients with T2DM.
Keywords
Coronary artery disease, type 2 diabetes mellitus, and interleukin - 6
Citation
Chittaragi et al. Bioinformation 19(12): 1134-1138 (2023)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
