Title
Molecular docking analysis of Indole based diaza-sulphonamides with JAK-3 protein
Authors
Manya Nautiyal1, Kavitha Sankaran*1, Surya Sekaran2, Gayathri Rengasamy1, Vishnu Priya Veeraraghavan1 & Rajalakshmanan Eswaramoorthy*2
Affiliation
1Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077; 2Department of Biomaterials (Green lab), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai-600077; Corresponding author
Manya Nautiyal – E-mail:152101057.sdc@saveetha.com
Kavitha Sankaran - E-mail:kavithas.sdc@saveetha.com
Surya Sekaran - E-mail:suryas.sdc@saveetha.com
Gayathri Rengasamy - E-mail:gayathri.sdc@saveetha.com
Vishnu Priya Veeraraghavan - E-mail:vishnupriya@saveetha.com
Rajalakshmanan Eswaramoorthy - E-mail:rajalakshmanane.sdc@saveetha.com
Article Type
Research Article
Date
Received January 1, 2023; Revised January 30, 2023; Accepted January 31, 2023, Published January 31, 2023
Abstract
JAK-3 gene is a part of an important signalling pathway in oral cancer. Therefore, it is of interest to evaluate the inhibitory properties of new indole based diaza-sulphonamides compounds against JAK3 gene. Molecular docking analysis showed that among the selected compounds (1-9), the compounds 1-4 turned out to be the most potentially capable ones to be used as ant-cancer drugs. Also, they are proved to be non-toxic.
Keywords
Oxadiazoles, indole, diaza-sulphonamides, anti-cancer, JAK-3
Citation
Nautiyal et al. Bioinformation 19(1): 74-78 (2023)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
