Title
Molecular docking analysis of PARγ with compounds from Ocimum tenuiflorum
Authors
Ponnulakshmi Rajagopal1, Selvaraj Jayaraman2, Shazia Fathima JH3, Saravanan Radhakrishnan4, Patil Ashlesh Laxman5, Vijaya Prakash Krishnan Muthaiah6, Satyendra Chandra Tripathi7, TS Gugapriya8, Aaditya Madhusudan Tarnekar8, Gayatri Girish Muthiyan8, Vishwajit Ravindra Deshmukh8, Bharat Ramrao Sontakke8 & Kirubhanand chandrashekar8,*
Affiliation
1Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India; 2Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India; 3Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, India; 4Department of Biochemistry, Karapaga Vinayaga Institute of Medical and Dental science, Madhuranthagam- 603308, Tamil Nadu, India; 5Department of Physiology, AIIMS, Nagpur 441108, India; 6Department of Rehabilitation Science, School of Public Health and Health professions, 633 Kimball, Buffalo NY, 14214-3079; 7Department of Biochemistry, AIIMS, Nagpur 441108, India; 8Department of Anatomy, AIIMS, Nagpur 441108, India; *Corresponding author
Kirubhanand chandrashekar - kirubhanand.c@gmail.com; Author contacts: ramgslaks@gmail.com; jselvaendo@gmail.com; shaziafathimarizwan@gmail.com; saravanabio@gmail.com; vijayapr@buffalo.edu; dr.ashlesh.p@aiimsnagpur.edu.in; vijayapr@buffalo.edu; sctripathi@aiimsnagpur.edu.in; gugapriyats@aiimsnagpur.edu.in; tarnekaram@aiimsnagpur.edu.in;gayatrimuthiyan@aiimsnagpur.edu.in; vishwajitdeshmukh@aiimsnagpur.edu.in; sontakkebr@aiimsnagpur.edu.in; kirubhanand@aiimsnagpur.edu.in;
Article Type
Research Article
Date
Received September 1, 2021; Revised October 18, 2021; Accepted October 18, 2021, Published November 30, 2021
Abstract
The ligand-activated transcription factor peroxisome proliferator-activated receptor (PPAR) has become a major target for type 2 diabetes. It belongs to the nuclear receptor superfamily, which controls the expression of proteins involved in glucose metabolism, lipid metabolism, adipocyte proliferation and differentiation, and insulin sensitivity. Ocimum tenuiflorum, often known as Krishna tulsi, is the most sacred herb in India. It was utilized for a variety of medicinal purposes. Therefore, it is of interest to document the molecular docking analysis data of PARγ modulators from Ocimum tenuiflorum. Four of the twenty substances (rosmarinic acid, permethrin, luteolin, and isosakuranetin) have a considerable binding affinity for the PPARγ. These phytochemicals are a source of potential anti-diabetic medicines.
Keywords
Diabetes, Proliferator-Activated Receptor – γ, Ocimum tenuiflorum, Molecular docking.
Citation
Rajagopal et al. Bioinformation 17(11): 928-931 (2021)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
