Title

Molecular docking analysis of beta-caryophyllene with IRS-1, cSrc and Akt

Authors

Vadivel Mani¹, Manikandan Balraj², Gayathri Venktsan³, Jagatheesh Soundrapandiyan⁴, Revathi Kasthuri⁴, Anandhi Danavel^5,* & Shyamaladevi Babu⁶

Affiliation

¹Department of Biochemistry, Arunai Medical College & Hospital, Tiruvanamallai-606603, Tamilnadu, India; ²Department of Physiology, Konaseema Institute of Medical sciences and research foundation, Amalapuram, East Godavari Dt-533201, Andhra Pradesh, India; ³Department of Physiology, Krishnadevaraya college of dental sciences and Hospital, Bangalore, Karanadakha, India; ⁴Department of Research, Meenakshi Academy of Higher Education, Chennai-600078, Tamilnadu, India; ⁵Department of biochemistry, Meenakshi Ammal Dental College & Hospital, Chennai-600095, Tamilnadu, India; ⁶Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India; ^*Corresponding author

Email

Anandhi Danavel - Email ID: thivyeshwar@gmail.com

Article Type

Research Article

Date

Received October 1, 2021; Revised October 18, 2021; Accepted October 18, 2021, Published November 30, 2021

Diabetes mellitus (DM) is a common metabolic illness defined by hyperglycemia caused by insufficient production or absent of pancreatic insulin, with or without concomitant insulin action impairment. Hence, novel problem-solving approaches for assessing early metabolic diseases, notably insulin resistance, are urgently needed. Screening of natural compounds for drug discovery to combat diabetes is common in modern medical research and development. Therefore, it is of interest to document the molecular docking analysis data of beta-Caryophyllene, a naturally occurring sequiterpene with the downstream insulin signaling molecules such as IRS-1, cSrc and Akt for the management of type-2 diabetes. The molecular docking analysis data of beta-caryophyllene with the insulin downstream signaling molecules such as IRS-1, cSrc and Akt reveals its ability and further studies are needed to elucidate its complete mechanism of action against type-2 diabetes.

Keywords

Diabetes mellitus; insulin resistance; Beta-Caryophyllene; molecular docking analysis; IRS-1; Akt

Citation

Mani et al. Bioinformation 17(11): 916-920 (2021)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.