Title

Insulin resistance and decreased spexin in Indian Patients with Type 2 Diabetes Mellitus

Authors

G Tejaswi¹, CD Dayanand^2,* & K Prabhakar³

Affiliation

¹Department of Biochemistry, Sri Devaraj Urs Academy of Higher Education & Research, Kolar, Karnataka, India; ²Department of Biochemistry, Sri Devaraj Urs Academy of Higher Education & Research, Kolar, Karnataka, India; ³Department of General Medicine, Sri Devaraj Urs Academy of Higher Education & Research, Kolar, Karnataka, India; *Corresponding author

Email

E-mail: drprabhakar@yahoo.in; Email idgtejaswisrinivas@ gmail.com; E-mail: cd8905@yahoo.co.in;

Article Type

Research Article

Date

Received August 27, 2021; Revised September 15, 2021; Accepted September 15, 2021, Published September 30, 2021

Spexin is novel biomarker, which plays a potential role in glucose and lipid metabolisms. However, there was paucity of serum spexin levels in obesity and diabetes mellitus subjects. Hence the current study was aimed to find the relationship between the serum spexin levels in type 2 Diabetes mellitus (type 2 DM) with extrapolation of cardiovascular disease (CVD) risk. A cross-sectional study included 330 participants, subdivided as control (n=110), type 2 DM (n=110) and type 2 DM with CVD groups (n=110). HbA1c, insulin, lipid profile, spexin & leptin including blood pressure and body mass index were analyzed from all the participants. The serum spexin levels (ng/ml) were significantly decreased in type 2 DM (mean ± sd: 0.65 ± 0.03) and type 2 DM with CVD (0.48 ± 0.02) groups compared to the control (0.79 ± 0.03) group (p<0.001). The decreased spexin levels were observed in type 2 DM, and further more decreased in type 2 DM with CVD patients compared to controls indicating that spexin levels could be served as an early prediction of obesity-induced T2DM with CVD risk.

Keywords

Cardiovascular disease, type 2 Diabetes Mellitus, Spexin

Citation

Tejaswi et al. Bioinformation 17(9): 790-797 (2021)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.