Title

Known data on CoVid-19 infection linked to type-2 diabetes

Authors

U. Vidhya Rekha¹, M. Anita², S. Bhuminathan¹ & K. Sadhana¹

Affiliation

¹Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600100, India; ²Department of Prosthodontics, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai 600100, India

Email

^*Corresponding author; Dr. U. Vidhya Rekha – E-mail: drvidhyarekha@gmail.com

Article Type

Review Article

Date

Received August 2, 2021; Revised August 30, 2021; Accepted August 30, 2021, Published August 31, 2021

It is of interest to document the known data on CoVid-19 infection linked to type-2 diabetes. Hyperglycemia, inhibition of neutrophil chemotaxis, altered cytokine synthesis, phagocytic cell dysfunction, impaired T cell-mediated immune responses, and inadequate microbia were all seen in people with Diabetes. Individuals with diabetes have also been shown to elevate levels of the proinflammatory cytokine, especially IL-1, IL-6, and tumor necrosis factor-alpha (TNF-alpha), and different markers such as C reactive protein, D-dimer, and fibrinogen. This will prolong the cytokine storms and lead to severe illness in diabetic individuals with COVID- 19 infection. The role of acute glycemic control after COVID- 19 manifestation on clinical outcomes has not been known in detail.
Known data shows that hyperglycemia facilitates local viral replication in the lungs and impairs anti-viral immune response. Thus, acute glycemic management plays an important role in limiting viral replication and disease progression in patients with diabetes. The available evidence implicates diabetes as important risk factors impacting the clinical severity of SARS-CoV-2.

Keywords

CoVid-19; type-2 diabetes; Inflammatory cytokines.

Citation

Vidhya Rekha et al. Bioinformation 17(8): 772-775 (2021)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.