Title

Efficacy of zirconium oxide nanoparticles coated onvstainless steel and nickel titanium wires in orthodontic treatment

Authors

Abirami Selvaraj^1,*, Ashwin Mathew George¹ & S. Rajeshkumar²

Affiliation

¹Department of Orthodontics and Dentofacial Orthopaedics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-77, India; ²Nanobiomedicine Lab, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai-77, India. ^*Corresponding author

Email

Abirami selvaraj - E-mail: varshaabi77@gmail.com; Ashwin Mathew George - E-mail: ashwinmathew.sdc@saveetha.com; S.Rajeshkumar – E-mail: ssrajeshkumar@hotmail.com

Article Type

Research Article

Date

Received June 24, 2021; Revised August 30, 2021; Accepted August 30, 2021, Published August 31, 2021

It is of particular intrigue to synthesize, analyze anti-bacterial, anti-inflammatory activity, cytotoxicity effect of clove and cardamom reinforced zirconium oxide nanoparticles to coat the orthodontic archwires and study its ramifications. Characterization of nanoparticles was done using Transmission electron microscopic analysis (TEM). Antimicrobial activity was assessed using agar well diffusion method. Cytotoxic effect was assessed using Brine Shrimp Assay. Anti-inflammatory activity was completed using Bovine Serum Albumin (BSA). A Digital magnetic stirrer with a hot plate was used to coat orthodontic arch wires such as NiTi and SS. TEM spherical shape was of size 5 -20 nm. Minimal cytotoxicity was observed at 50 ĴL. Anti-inflammatory property was fair. Antimicrobial
activity against Lactobacillus species, streptococcus mutans staphylococcus aureus and Candida albicans was recorded. NiTi and SS showed a colour shift from silver to orange red with a uniform surface coating on wires. Thus, green synthesized zirconium oxide nanoparticles have potent antimicrobial, anti-inflammatory properties with minimal cytotoxicity for further consideration as nanocoatings on orthodontic archwires such as NiTi and Stainless Steel.

Keywords

clove and cardamom, zirconium oxide nanoparticles, antibacterial, anti inflammatory, cytotoxicity, TEM.

Citation

Selvaraj et al. Bioinformation 17(8): 760-766 (2021)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.