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Title |
Molecular docking analysis of COX-2
with compounds from Piper longum
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Authors |
Dhirendra Tripathi1, Sravanthi Koora2,
K Satyanarayana3, S Saleem Basha4,* & Selvaraj Jayaraman5 |
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Affiliation |
1Department of Otorhinolaryngology,
Government Medical College, Shivpuri, Shivpuri - 473638; 2Department
of Pharmacology, Government Medical College Siddipet 502103,
Siddipet, Telangana; 3Department of Biochemistry, Government Medical
College Siddipet, Siddipet 502103, Telangana India; 4Department of
Medical Biochemistry, School of Medicine, Haramaya university, Harar
Campus, Ethiopia; 5Department of Biochemistry, Saveetha Dental
College and Hospitals, Saveetha Institute of Medical and Technical
Sciences, Chennai-600 077, India |
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Email |
Corresponding author*; Dr. S. Saleem
Basha; Email: saleem.basha09@gmail.com |
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Article Type |
Research Article
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Date |
Received April 25, 2021; Revised May
27, 2021; Accepted May 28, 2021, Published June 30, 2021
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Abstract |
Piper longum (Indian long
pepper) is known for its use as an anti inflammatory agent in Indian
Ayurvedic System of medicine. Therefore, it is of interest to
document the molecular docking analysis of compounds from Piper
longum with COX-2 using the Autodock Vina PyRx tool.
Molecular docking results show that asarinine, sesamine, fargesin,
and piperlonguminine have optimal binding energy of ¹10, ¹10, -9.5
and ¹9.4 Kcal/mol, respectively for further consideration. |
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Keywords |
Anti-inflammatory compunds, COX-2,
Piper longum, molecular docking |
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Citation |
Tirupathi et al. Bioinformation 17(6):
623-627 (2021) |
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Edited by |
P Kangueane
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ISSN
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0973-2063
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Publisher |
Biomedical Informatics
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License |
This is an Open Access article which permits unrestricted use,
distribution, and reproduction in any medium, provided the original
work is properly credited. This is distributed under the terms of
the
Creative Commons Attribution License.
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