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Title

Molecular docking analysis of COX-2 with compounds from Piper longum

 

Authors

Dhirendra Tripathi1, Sravanthi Koora2, K Satyanarayana3, S Saleem Basha4,* & Selvaraj Jayaraman5

 

Affiliation

1Department of Otorhinolaryngology, Government Medical College, Shivpuri, Shivpuri - 473638; 2Department of Pharmacology, Government Medical College Siddipet 502103, Siddipet, Telangana; 3Department of Biochemistry, Government Medical College Siddipet, Siddipet 502103, Telangana India; 4Department of Medical Biochemistry, School of Medicine, Haramaya university, Harar Campus, Ethiopia; 5Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai-600 077, India

 

Email

Corresponding author*; Dr. S. Saleem Basha; Email: saleem.basha09@gmail.com

 

Article Type

Research Article

 

Date

Received April 25, 2021; Revised May 27, 2021; Accepted May 28, 2021, Published June 30, 2021

 

Abstract

Piper longum (Indian long pepper) is known for its use as an anti inflammatory agent in Indian Ayurvedic System of medicine. Therefore, it is of interest to document the molecular docking analysis of compounds from Piper longum with COX-2 using the Autodock Vina PyRx tool.
Molecular docking results show that asarinine, sesamine, fargesin, and piperlonguminine have optimal binding energy of 10, 10, -9.5 and 9.4 Kcal/mol, respectively for further consideration.

 

Keywords

Anti-inflammatory compunds, COX-2, Piper longum, molecular docking

 

Citation

Tirupathi et al. Bioinformation 17(6): 623-627 (2021)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.