Antioxidant, antimicrobial and cytotoxicity of nhexane extract from Mollugo nudicaulis Lam.

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Title	*Antioxidant, antimicrobial and cytotoxicity of nhexane extract from Mollugo nudicaulis* Lam.**
Authors	Siva Shankar Raj¹, Chella Perumal Palanisamy² & Mani Panagal^1*
Affiliation	¹Department of Biotechnology, Annai College of Arts and Science, Kovilacheri, Tamil Nadu, India; email: nirmal2014@gmail.com (S.S.R), mani.panagal@yahoo.com (M.P); ²State Key Laboratory of Biobased Material and Green Papermaking, College of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China
Email	E-mail: perumalbioinfo@gmail.com Corresponding Author*; Panagal Mani - Email: mani.panagal@yahoo.com; Mobile: +91-9976918228
Article Type	Research Article
Date	Received April 25, 2021; Revised May 28, 2021; Accepted May 28, 2021, Published May 31, 2021
Abstract	The antioxidant, antimicrobial and anticancer activity of n-hexane extract of Mollugo nudicaulis Lam. is of interest. The antioxidant activity of the extract was determined by separate methods of radical scavenging assays. Antimicrobial activity was analyzed by disc diffusion method on fungi species, gram positive and negative species. The anticancer potential of plant extract was evaluated on A2780 cell lines by MTT assay. Results exposed that, the n-hexane extract of M.nudicaulis possess comparable significant antioxidant activity with IC50 values of 12.79ą0.82, 36.65ą0.03 and 19.59ą0.26 μg/mL, on DPPH, nitric oxide and hydroxyl radical scavenging assays respectively, and also possess notable reducing power of 0.84ą0.04 (Reducing power assay) and 0.75ą0.02 (FRAB assay) at the maximum concentration of 200 μg/mL of the n-hexane extract. Antimicrobial activity of extract exhibited maximum zone of inhibition ranged from 11.1 ą 0.3 to 14 .5ą 0.3 mm on tested microorganism. The anticancer activity of plant extract found to be strong cell growth inhibitory activity with minimal IC50 values of 32.46ą0.92 μg/mL on A2780 cell lines. Collectively this study can be concluded that, the n-hexane extract of M.nudicaulis might act as possible antioxidant, antimicrobial and anticancer agents.
Keywords	M. nudicaulis; n-hexane extract; antioxidant activity; antimicrobial activity; anticancer activity
Citation	Raj et al. Bioinformation 17(5): 573-582 (2021)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.