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Title

Antioxidant, antimicrobial and cytotoxicity of nhexane extract from Mollugo nudicaulis Lam.

 

Authors

Siva Shankar Raj1, Chella Perumal Palanisamy2 & Mani Panagal1*

 

Affiliation

1Department of Biotechnology, Annai College of Arts and Science, Kovilacheri, Tamil Nadu, India; email: nirmal2014@gmail.com (S.S.R), mani.panagal@yahoo.com (M.P); 2State Key Laboratory of Biobased Material and Green Papermaking, College of Food Science and
Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China

 

Email

E-mail: perumalbioinfo@gmail.com Corresponding Author*; Panagal Mani - Email: mani.panagal@yahoo.com; Mobile: +91-9976918228

 

Article Type

Research Article

 

Date

Received April 25, 2021; Revised May 28, 2021; Accepted May 28, 2021, Published May 31, 2021

 

Abstract

The antioxidant, antimicrobial and anticancer activity of n-hexane extract of Mollugo nudicaulis Lam. is of interest. The antioxidant activity of the extract was determined by separate methods of radical scavenging assays. Antimicrobial activity was analyzed by disc diffusion method on fungi species, gram positive and negative species. The anticancer potential of plant extract was evaluated on A2780 cell lines by MTT assay. Results exposed that, the n-hexane extract of M.nudicaulis possess comparable significant antioxidant activity with IC50 values of 12.790.82, 36.650.03 and 19.590.26 μg/mL, on DPPH, nitric oxide and hydroxyl radical scavenging assays respectively, and also possess notable reducing power of 0.840.04 (Reducing power assay) and 0.750.02 (FRAB assay) at the maximum concentration of 200 μg/mL of the n-hexane extract. Antimicrobial activity of extract exhibited maximum zone of inhibition ranged from 11.1 0.3 to 14 .5 0.3 mm on tested microorganism. The anticancer activity of plant extract found to be strong cell growth inhibitory activity with minimal IC50 values of 32.460.92 μg/mL on A2780 cell lines. Collectively this study can be concluded that, the n-hexane extract of M.nudicaulis might
act as possible antioxidant, antimicrobial and anticancer agents.

 

Keywords

M. nudicaulis; n-hexane extract; antioxidant activity; antimicrobial activity; anticancer activity

 

Citation

Raj et al. Bioinformation 17(5): 573-582 (2021)

 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.