Title
Effect of Myristica fragrans extract on total body composition in cafeteria diet induced obese rats
Authors
1Vangoori Yakaiah*, 2Anusha Dakshinamoorthi*, 3Subramanian Kavimani
Affiliation
1Santhiram Medical College, Nandyal (AP). (PhD)-SRIHER, Chennai; 2Sri Ramachandra Institute of Higher Education and Research. Chennai; 3Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry.
Anusha Dakshinamoorthi - drdanusha@gmail.com, *Corresponding author:
Article Type
Research Article
Date
Received September 30, 2019; Revised October 7, 2019; Accepted October 9, 2019; Published October 13, 2019
Abstract
It is of interest to evaluate the effect of Myristica fragrans on
body composition of cafeteria diet induced obese rats. Thirty rats
(150-160g)
grouped into 5 and each group contains 6 rats. Group-1 was normal
control and 2-5 groups were fed with cafeteria diet for 15 weeks to
induce obesity. From 16th week to 25th week test drugs were given as
mentioned in the experimental protocol. Body weight, BMI, changes
in body composition was measured by TOBEC, adipose tissue weights,
organ weights, abdominal circumference were measured according
to standard methods. After 70days of treatment with MFE 200mg/kg,
400mg/kg Body weight reduced by 9.29%, 12.87% respectively. BMI
was also decreased. Abdominal circumference, total fat percentage,
organ weights, was substantially reduced. At 400mg/kg of MFE has
shown maximum potentiality when compared with 200mg/kg. Orlistat
50mg was used as standard drug. Tetrahydrofuran, flavonoids,
saponins, present in Myristica fragrans has shown anti obesity
activity. Our findings explain the potentiality of phytochemicals as
a potent
anti obesity agent, provide scientific evidence for its traditional
use and suggest the possible mechanism of action.
Keywords
Obesity, BMI, abdominal circumference, total fat, adiposity index, tetra hydrofuran.
Citation
Yakaiah et al. Bioinformation 15(9): 657-665 (2019)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
