Title

Effect of salvia Officinalis L. and Rosmarinus Officinalis L. leaves extracts on anxiety and neural
activity

Authors

Zineb Choukairi¹,*, Tahar Hazzaz¹, Mustapha Lkhider¹, José Manuel Ferrandez² & Taoufiq Fechtali¹

Affiliation

¹Laboratory of Biosciences, Functional, integrated and molecular exploration, School Of Sciences and Technology - Mohammedia, Hassan II University of Casablanca; ²Laboratory Of "Inteligencia Ambiental", Polytechnic University of Cartagena, Spain;

Email

Zineb Choukairi - E-mail: choukairizineb@gmail.com; *corresponding author

Article Type

Research Article

Date

Received October 6, 2018; Accepted October 19, 2018; Published March 15, 2019

Anxiety, the illness of our time, is one of the most prevalent and co-morbid psychiatric disorder that represents a significant socioeconomic burden. Conventional treatment is associated with a number of side effects and there is a need to develop new therapeutic strategies. Therefore, it is of interest to investigate the modulating effects of Salvia Officinalis L. and Rosmarinus Officinalis L. leaves extracts on anxiety using different behavioral tests, and on neural activity using the Multi-electrode array technique. Data shows the decrease of the time of the immobility associated with a significant increase in the time spent in the center of the open field arena in the treated animals compared to the controls. The number of buried marbles has also decreased in the treated animals in the marble-burying test. On the other hand results also show a decrease of the neural activity explained by a decrease of the number of spikes after 24,48 and 72 h following the addition of 12,5 μg/ml of the plant leaf extracts to the neural culture. However, there were no spikes after the administration of 25μg/ml of the plants extracts.

Keywords

Anxiety, Rosmarinus Officinalis L., Salvia Officinalis L., neural activity, GABA.

Citation

Choukairi et al. Bioinformation 15(3): 172-178 (2019)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.