Title

Re-positioning of known drugs for Pim-1 kinase target using molecular docking analysis

Authors

Housna Arrouchi^1*, Wiame Lakhlili¹ & Azeddine Ibrahimi¹

Affiliation

¹Biotechnology Laboratory (Medbiotech), BioInova Research center, Rabat Medical and Pharmacy School, Mohammed V University in Rabat, Rabat, Morroco

Email

Housna Arrouchi - E-mail: Housna.arrouchi@um5s.net.ma; *Corresponding Author

Article Type

Research Article

Date

Received January 19, 2019; Revised February 1, 2019; Accepted February 1, 2019; Published February 28, 2019

The Concept of reusing existing drugs for new targets is gaining momentum in recent years because of cost-effectiveness as safety and toxicology data are already available. Therefore, it is of interest to re-profile known drugs against the Pim-1 kinase target using molecular docking analysis. Results show that known drugs such as nilotinib, vemurafenib, Idelalisib, and other small kinases inhibitors have high binding ability with Pim-1 kinase for consideration as potential inhibitors.

Keywords

drug re-profiling, Pim-1 kinase, small kinases inhibitors

Citation

Arrouchi et al. Bioinformation 15(2): 116-120 (2019)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.