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Title |
Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis
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Authors |
Ipsita Das1, Hrishikesh Mishra2, Prafulla K. Khodiar1, Pradeep K. Patra1*
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Affiliation |
1Pt. J.N.M. Medical College, Raipur, India; 2Sickle Cell Institute Chhattisgarh, Raipur, India
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pkp1964@yahoo.co.in
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Article Type |
Hypothesis
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Date |
Received July 24, 2018; Revised July 29, 2018; Accepted July 29, 2018; Published July 31, 2018
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Abstract |
Sickle cell disease (SCD) is life-threatening hemoglobinopathy prevalent in India, Sub-Saharan Africa and Middle East. Inflammation plays a pivotal role in disease process and involves intricate interaction among leukocytes, platelets, sickle erythrocytes and vascular endothelium. Available disease modifying therapies are hydroxyl-urea and blood transfusion. Therefore, it is of interest to develop improved pharmacological agents for SCD. We report up-regulated genes in steady state and vaso-occlusive crisis using analysis of gene expression data obtained by microarray experiment for SCD as potential targets. The association of these targets with inflammation in pathway analysis is also documented.
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Keywords |
Sickle cell disease; vaso-occlusive crisis; inflammation; gene expression; pathophysiology; drug targets.
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Citation |
Das et al. Bioinformation 14(7): 408-413 (2018)
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
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