Title

Analysis of antibiotics resistant genes in different strains of Staphylococcus aureus

Authors

Benson Otarigho^1,2*, Mofolusho O. Falade³

Affiliation

¹Department of Biological Science, Edo University, Iyamho, Edo State, Nigeria;

²Department of Molecular Microbiology and Immunology, School of Medicine, Oregon Health and Science University, Portland, OR USA;

³Cellular Parasitology Programme, Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria;

Email

otarigho.benson@edouniversity.edu.ng; otarighobenson152799@gmail.com;

Article Type

Hypothesis

Date

Received January 22, 208; Revised February 21, 2018; Accepted February 21, 2018; Published March 31, 2018

The control of Staphylococcus aureus infection is being hampered by methicillin and other resistant strains. The identification of the unique antibiotic resistant genes from the genomes of various strains of S. aureus is of interest. We analyzed 11 S. aureus genomes sequences for Antibiotics Resistance Genes (ARGs) using CARD 2017 platform. We identified 32 ARGs across 11 S. aureus strains. Tet(38), norB, lmrB, mepA and mepR were present across genomes except for S. aureus strain UTSW MRSA 55. The mepA and mepR were found across 11 different genomes. However, FosB3, vgaALC, mphC and SAT-4 were found in UTSW MRSA 55, S.a. strain ISU935 and S.a. strain FDAARGOS_159. The prevalent mode of mechanism of antibiotics resistant was efflux pump complex or subunit conferring antibiotic resistance as well as protein(s). Analysis of norB, ImrB, norA, ImrB, tet (38), sav1866 and mecA have 12 to 14 TMHs. The results help in the understanding of Staphylococcus aureus pathogenesis in the context of antibiotic resistance.

Keywords

Staphylococcus aureus, Resistant Genes, Pathogens, Bacteria

Citation

Otarigho et al. Bioinformation 14(3): 113-122 (2018)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.