Title

Analysis of correlated mutations in Ras G-domain

Authors

Ekta Pathak^1,*

Affiliation

Bioinformatics Department, MMV, Banaras Hindu University.

Email

ektavpathak@gmail.com

Article Type

Hypothesis

Date

Received June 11, 2017; Accepted June 21, 2017; Published June 30, 2017

Ras GTPases are most prevalent proto-oncogenes in human cancer. Mutations in Ras remain untreatable more than three decades after the initial discovery. At the amino acid level, some residues under physical or functional constraints exhibit correlated mutations also known as coevolving/covariant residues. Revealing intra-molecular co-evolution between amino acid sites of proteins has become an emerging area of research as it enlightens the importance of variable regions. Here, I have identified and analyzed the coevolving residues in the Ras GTP binding domain (G-domain). The obtained covariant residue position data correlate well with the known experimental data on functionally important residues. Therefore, it is of interest to understand these residue co-variations for designing protein engineering experiments and target oncogenic Ras GTPases.

Keywords

Ras, GTPases, G-domain, Coevolution, Correlated Mutation

Citation

Pathak, Bioinformation 13(6): 174-178 (2017)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.