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Title |
Sequence to functional analysis of LPAR6 mutants using structural molecular models
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Authors |
Samina A. Khan
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Affiliation |
Medical Education Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia;
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*Samina A. Khan- Email: samina.amanullah@gmail.com; *Corresponding author
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Article Type |
Hypothesis
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Date |
Received August 2, 2016; Revised December 21, 2016; Accepted December 22, 2016; Published December 30, 2016
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Abstract |
The human hair has compound structures with several known biological functions. Hereditary hair loss is caused by a heterogeneous group of disorders. LPAR6 gene is associated with hair loss or baldness, which is characterized by sparse scalp hair, sparse to absent eyebrows and eyelashes, and sparse auxiliary and body hair. Mutant variants of LPAR6 gene and its corresponding P2RY5 protein sequences are available in GenBank. Therefore, it is of interest to study their mutational effect in these variants using P2RY5 protein homology based molecular models (Protein Model Database (PMDB) ID: PM0077839). The differences in subtle structural features with calculated physiochemical properties in various P2RY5 protein variants are documented in this study using mutant models. This data will provide insight in the understanding of cellular functions responsible for the growth of hair follicles with reference to baldness in human.
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Keywords |
LPAR6, P2RY5, structure prediction, hair loss, trans-membrane segmentation
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Citation |
Khan, Bioinformation 12(12): 430-435 (2016)
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
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