Alkyloxy carbonyl modified hexapeptides as a high affinity compounds for Wnt5A protein in the treatment of psoriasis

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Title	Alkyloxy carbonyl modified hexapeptides as a high affinity compounds for Wnt5A protein in the treatment of psoriasis
Authors	Ankit Kelotra¹*, Sadashiv M Gokhale¹, Seema Kelotra², Vaidehi Mukadam⁴, Komal Nagwanshi⁴, Srinivas Bandaru³, Anuraj Nayarisseri⁴ & Anil Bidwai⁵
Affiliation	¹School of Biochemistry, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore (M.P.) – 452 017, India; ²M.B Khalsa College, Near Gangwal Bus Stand, Indore (M.P.)-452011, India; ³Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad – 500 016, India; ⁴In silico Research Laboratory, Eminent Biosciences, Indore – 452 010, India; ⁵Index medical College, Indore (M.P)-452010, India
Email	ankitkelotra22@gmail.com; *Corresponding author
Article Type	Hypothesis
Date	Received December 18, 2014; Accepted December 24, 2014; Published December 31, 2014
Abstract	Psoriasis is one of the most prevalent chronic inflammatory diseases of the skin. The Wnt pathways have been documented to play essential role in stem cell self-renewal and keratinocyte differentiation in the skin. Antagonizing the Wnt5a protein would emerge as a novel therapeutics in psoriasis treatment. In this view, we have developed and characterized series of compounds by attaching varied tertiary alkyloxy carbonyl groups at the N-terminal end of the hexapeptide (Met-Asp-Gly-Cys-Glu-Leu) bestowed to inhibit Wnt/Ca2+ signaling in psoriasis. Hexapeptide compound with 1,1-diphenylethoxy carbonyl group attached to N-terminal end of hexapeptide demonstrated highest binding affinity amongst all the evaluated compounds. The compound identified in the study can be subjected further for in vitro and in vivo studies for ADMET properties.
Keywords	Psoriasis, Wnt5A, Protein Modeling, Alkyloxy carbonyl modified hexapeptides, Molecular docking
Citation	*Kelotra et al.* Bioinformation 10(12): 743-749 (2014)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.