Screening and design of anti-diabetic compounds sourced from the leaves of neem (Azadirachta indica)

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Title	Screening and design of anti-diabetic compounds sourced from the leaves of neem (Azadirachta indica)
Authors	Asma Jalil¹, Usman Ali Ashfaq¹, Samar Shahzadi¹, Muhammad Rizwan Javed¹, Ijaz Rasul¹, Shahid-ur Rehman², Masaud Shah³, Muhammad Shareef Masoud¹*
Affiliation	¹Department of Bioinformatics and Biotechnology, Government College University (GCU), Faisalabad, Pakistan; ²Department of Poultry Husbandry, University of Agriculture, Faisalabad, Pakistan; ³Department of Biochemistry, Abdul Wali Khan University, Mardan, Pakistan
Email	masoudshareef@gmail.com; *Corresponding author
Article Type	Hypothesis
Date	Received September 13, 2013; Accepted September 13, 2013; Published December 27, 2013
Abstract	Diabetes Mellitus is affecting people of all age groups worldwide. Many synthetic medicines available for type 2 diabetes mellitus in the market. However, there is a strong requirement for the development of better anti-diabetes compounds sourced especially from natural sources like medicinal plants. The extracts from the leaves of neem (Azadirachta indica) is traditionally known to have anti-diabetes properties. Therefore, there is an increased interest to identify potential compounds identified from neem leaf extracts showing predicted binding property with the known diabetes mellitus type 2 protein enzyme target phosphoenol-pyruvate carboxykinase(PEPCK). The structure data for compounds found in the leaf extract of neem was screened against PEPCK using molecular docking simulation and screening techniques. Results show that the compound 3-Deacetyl-3-cinnamoyl-azadirachtin possesses best binding properties with PEPCK. This observation finds application for further consideration in in vitro and in vivo validation.
Citation	Jalil et al. Bioinformation 9(20): 1031-1035 (2013)
Edited by	P Kangueane
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.