Title

Authors

Affiliation

Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, 201307, Uttar Pradesh, India

Email

vibha.rani@jiit.ac.in; *Corresponding author

Article Type

Hypothesis

Date

Received August 22, 2013; Revised August 29, 2013; Accepted August 00, 2013; Published November 11, 2013

MicroRNAs (miRNAs) are the naturally expressed small, 18~25 nts long non-coding single stranded RNAs, which inhibit the translation by interacting with the 3’ untranslated region (UTR) of specific mRNA targets or by repression of posttranscriptional modification of mRNAs. MiRNAs are found to regulate the differentiation, development, function and stress responsive growth of cardiac cells. Their role and association with several disease progressions is of interest in recent years. Our interest is to study their role in cardiac hypertrophy (characterized by increased cell size, protein synthesis and reactivation of gene pathways). Therefore, we analyzed their features using a dataset (# ≈1400 #) of potential intronic and 3’UTR targeted miRNAs from known cardiac marker genes. We report 10 uncharacterized miRNAs regulating cardiac marker genes during cardiac hypertrophy and other cardiac diseases.

Citation

Rustagi & Rani,   Bioinformation 9(18): 919-922 (2013)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.