|
Title |
Agonistic approach of omega-3, omega-6 and its metabolites with BDNF: An In-silico study
|
|
Authors |
Yadla Phani Kumar1*, G Sri Shanmukha Srinivas1, Yadu Mitravinda E1, Lalitha Malla2, Allam Appa Rao1, 2
|
|
Affiliation |
1C R RAO Advanced Institute of Mathematics Statistics and Computer Science, University of Hyderabad campus, Gachibowli, Hyderabad-500046; 2Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh - 533 003 |
|
|
phani.yadla@gmail.com; *Corresponding author |
|
Article Type |
Hypothesis |
|
Date |
Received October 04, 2013; Accepted October 19, 2013; Published November 11, 2013
|
|
Abstract |
Brain derived neurotrophic factor (BDNF) is a member of neurotrophic family of growth factors, mainly found in the hippocampus and cerebral cortex of brain. Studies have shown that there is a link between BDNF and cognitive dysfunction, as well as there is a relationship between the PUFAs intake and their effect on BDNF production. Intake of PUFAs, mainly omega-3 and omega-6 has show increase in production of BDNF in brain. In our study we performed docking studies on PUFAs and their metabolites with BDNF using MVD (Molegro Virtual Docker), this has shown that the metabolites of the PUFAs mainly LXA_4, NPD1, HDHA have shown more binding affinity towards BDNF. These metabolites of PUFAs are responsible for modulation of BDNF activity. |
|
Keywords |
CBDNF, PUFA, Cognitive dysfunction, LXA_4, NPD1, HDHA, MVD, Evolutionary algorithm, cavity detection algorithm, Escore.
|
|
Citation |
Kumar et al.
Bioinformation 9(18): 908-911 (2013) |
|
Edited by |
P Kangueane
|
|
ISSN |
0973-2063
|
|
Publisher |
|
|
License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |