Title

Authors

Affiliation

Centre for Biotechnology, University of Allahabad, Allahabad, U.P-211002, India

Email

sukratsinha@gmail.com; *Corresponding author

Date

Received September 03, 2013; Accepted September 05, 2013; Published September 23, 2013

The Leishmania homologue of activated C kinase (LACK) a known T cell epitope from soluble Leishmania antigens (SLA) that confers protection against Leishmania challenge. This antigen has been found to be highly conserved among Leishmania strains. LACK has been shown to be protective against L. donovani challenge. A comprehensive analysis of several LACK sequences was completed. The analysis shows a high level of conservation, lower variability and higher antigenicity in specific portions of the LACK protein. This information provides insights for the potential consideration of LACK as a putative candidate in the context of visceral leishmaniasis vaccine target.

Keywords

Next-generation sequencing, Genome Assembly, Bioinformatics.

Citation

Sinha et al.  Bioinformation 9(16): 832-837 (2013)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.