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Title |
Porphyrin derivatives as inhibitors for acetylcholinesterase from Drosophila melanogaster |
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Authors |
Abdul Hai1*, Nadeem A. Kizilbash1, SyedaHuma H. Zaidi2 & Jamal Alruwaili1
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Affiliation |
1Department of Biochemistry, Faculty of Medicine & Applied Medical Sciences, Northern Border University; 2Department of Chemistry, Faculty of Science, Northern Border University, P.O. Box 1321, Arar-91431, Saudi Arabia |
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ahaiksa@gmail.com; *Corresponding author |
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Article Type |
Hypothesis |
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Date |
Received May 22, 2013; Accepted May 27, 2013; Published July 12, 2013
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Abstract |
The cure for Alzheimer's disease (AD) is still unknown. According to Cholinergic hypothesis, Alzheimer’s disease is caused by the reduced synthesis of the neurotransmitter, Acetylcholine. Regional cerebral blood flow can be increased in patients with Alzheimer’s disease by Acetylcholinesterase (AChE) inhibitors. In this regard, Tetraphenylporphinesulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinatoIron(III) nitrosyl Chloride (FeNOTPPS) were investigated as candidate compounds for inhibition of Acteylcholinesterase of Drosophila melanogaster (DmAChE) by use of Molecular Docking. The results show that FeNOTPPS forms the most stable complex with DmAChE. |
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Keywords |
Acetylcholinesterase, Acetylcholinesterase inhibitors, Cholinergic hypothesis, Porphyrin derivatives, Molecular Docking.
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Citation |
Hai et al.
Bioinformation 9(12): 645-649 (2013) |
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |