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Title |
Insight from βC1 protein model for implication in cotton leaf curl disease
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Authors |
Khuram Shahzad1, Abdul Hai2, Nadeem Kizilbash2*, Jawaria Ambreen3 & Jamal Alruwaili2
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Affiliation |
1Illinois Informatics Institute, University of Illinois, Urbana-Champaign, Illinois, U.S.A; 2Department of Biochemistry, Faculty of Medicine & Applied Medical Sciences, Northern Border University, Arar-91431, Saudi Arabia; 3Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan |
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nadeem_kizilbash@yahoo.com; *Corresponding author |
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Article Type |
Hypothesis |
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Date |
Received March 03, 2013; Accepted April 01, 2013; Published May 25, 2013
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Abstract |
DNA β is approximately half of the size of Begomovirus DNA. It encodes a βC1 gene that is conserved in position and size. This gene has the capacity to encode a 13 to 14 kDa protein comprising 118 amino acid residues. It has been shown earlier that βC1 protein is necessary for inducing symptoms of cotton leaf curl disease. The structure for βC1 (CLCuDβ01-Pakistan) is still unknown. Therefore, a model of βC1 (CLCuDβ01-Pakistan) was developed using DoBo and I-TASSER servers followed by validation by PROCHECK and VERIFY 3D servers. The developed model provides an insight in a role for this multifunctional protein in causing Cotton Leaf Curl Disease (CLCuD). A possible function of this protein might be the suppression of RNA-silencing in cotton plants. |
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Keywords |
Cotton Leaf Curl Disease, DNA β, βC1 gene, threading, protein structure prediction, RNA silencing.
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Citation |
Shahzad et al.
Bioinformation 9(9): 471-476 (2013) |
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |