Title

Authors

Affiliation

¹Department of Bioscience, Integral University, Lucknow-226026; ²Council of Science and Technology, Uttar Pradesh

Email

humamustafa1@yahoo.co.in; *Corresponding author

Article Type

Hypothesis

Date

Received February 02, 2013; Accepted February 18, 2013; Published March 02, 2013

Glutathione-S-transferase is a major phase-II detoxification enzyme in parasitic helminthes. Previous research highlights the importance of GSTs in the establishment of chronic infections in cytotoxic microenvironments. Filarial nematodes depend on these detoxification enzymes for their survival in the host. GST plays an important role in filariasis and other diseases. GST from W.bancrofti and B.malayi are very much different from human GST. This structural difference makes GST potential chemotherapeutic targets for antifilarial treatment. In this study we have checked the efficacy of some well known antifilarial compounds against GST from B.malayi and W.bancrofti. The structure of BmGST was modeled using modeller9v10 and was submitted to PMDB. Molecular docking study reveals arbindazole to be the most potent compounds against GST from both the filarial parasites. Role of some residues playing important role in the binding of compounds within the active site of GST has also been revealed in the present study. The BmGST and WbGST structural information and docking studies could aid in screening new antifilarials or selective inhibitors for chemotherapy against filariasis.  

Abbreviations

GST: Glutathione-S-transferase, Bm: Brugia malayi, Wb: Wuchereria bancrofti.

Citation

Saeed et al.   Bioinformation 9(5): 233-237 (2013)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.