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Title |
Current opinion on an emergence of drug resistant strains of Plasmodium falciparum through genetic alterations
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Authors |
Kondapalli Kasturi*, Donepudi Siva Mallika, Seelam Jeevan Amos, Pavithra Venkateshaiah & KRS Sambasiva Rao |
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Affiliation |
Department of Biotechnology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India
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kasturi.is.kodapalli21@gmail.com; *Corresponding author
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Article Type |
Hypothesis |
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Date |
Received August 15, 2012; Revised September 05, 2012; Accepted October 17, 2012; Published November 13, 2012
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Abstract |
The human malarial parasite Plasmodium falciparum is one of the world’s most devastating pathogen. Its capability to regulate its genes under various stages of its life cycle as well as under unfavourable environmental conditions has led to the development of vaccine resistant strains. Similarly, under drug pressure it develops mutations in the target genes. These mutations confer mid and high-level resistance to the antimalarial drugs. Increasing a resistance of malaria parasites to conventional antimalarial drugs is an important factor contributing to the persistence of the disease as a major health threat. This article reviews current knowledge of stage specific malarial targets, antimalarial drugs and the mutations that have led to the emergence of resistant strains.
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Keywords |
Malaria, Plasmodium falciparum, Antimalarial drugs, Mutations, Stage specific protein targets.
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Citation |
Kasturi et al.
Bioinformation 8(22): 1114-1118 (2012) |
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |