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Title

Structure based virtual screening of inhibitors for binding at the allosteric site of HCV RNA dependent RNA polymerase

 

Authors

Amjesh Revikumar1*, Achuthsankar Sukumaran Nair1 & Sugunan Vetha Sundaram2

 

Affiliation

1Centre for Bioinformatics, University of Kerala, Trivandrum 695581, India; 2Department of Zoology, His Highness The Maharaja's University College, Trivandrum, 695034, Kerala, India.

 

Email

amjesh@gmail.com; *Corresponding author

 

Article Type

Hypothesis

 

Date

Received December 11, 2011; Accepted December 22, 2011; Published August 03, 2012

 

Abstract

Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality. There is no effective treatment or prevention till date for HCV infection. We describe the computed binding of 10 compounds to the allosteric binding site of RNA dependent RNA polymerase enzyme. These compounds were identified from the ZINC database through virtual screening followed by ADMET evaluation.

 

Citation

Revikumar et al. Bioinformation 8(15): 716-719 (2012)
 

Edited by

P Kangueane

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.