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Title |
Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis |
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Authors |
Ameeruddin Nusrath Unissa1*, Subramanian Sudha2, Nagamiah Selvakumar1, Sameer Hassan3 |
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Affiliation |
1Department of Mycobacteriology, National Institute for Research in Tuberculosis (NIRT), Indian Council of Medical Research (ICMR), Mayor V.R. Ramanathan Road, Chetput, Chennai - 600 031, Tamil Nadu, India; 2Veterinary College, Chennai - 600 031, Tamil Nadu, India; 3Department of Biomedical Informatics Centre, NIRT, (ICMR), Mayor V.R. Ramanathan Road, Chetput, Chennai - 600 031, Tamil Nadu, India
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nusrathunissa@gmail.com; *Corresponding author
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Fax |
+91-(044)-2836 2528
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Article Type |
Hypothesis
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Date |
Received July 30, 2011; Accepted August 17, 2011; Published September 28, 2011
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Abstract |
AccD6 (acetyl coenzyme A (CoA) carboxylase), plays an important role in mycolic acid synthesis of Mycobacterium tuberculosis (Mtb). Induced gene expression by isoniazid (isonicotinylhydrazine - INH), anti-tuberculosis drug) shows the expression of accD6. It is our interest to study the binding of activated INH with the AccD6 model using molecular docking procedures. The study predicts a primary binding site for activated INH (isonicotinyl acyl radical) in AccD6 as a potential target.
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Keywords |
M. tuberculosis, modeling, docking, AccD6, INH, INADH, acetyl-CoA.
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Citation |
Unissa et al.
Bioinformation 7(3): 107-111 (2011) |
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Edited by |
P Kangueane
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ISSN |
0973-2063
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Publisher |
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License |
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |