Title

Authors

Affiliation

¹Center of Bioinformatics, University of Allahabad, Allahabad, India; ²Department of Biochemistry, University of Allahabad, Allahabad, India

Email

vijaytripathi84@gmail.com; *Corresponding author

Phone

+91-9452599741

Article Type

Hypothesis

Date

Received June 09, 2011; Accepted June 28, 2011; Published July 06, 2011

Malaria, one of the world’s most common diseases, is caused by the intracellular protozoan parasite known as Plasmodium. In this study, we have determined the evolutionary relationship of two single-copy proteins, circumsporozoite protein (CSP) and merozoite surface protein-1 (MSP-1), among Plasmodium species using various bioinformatics tools and softwares. These two proteins are major blood stage antigens of Plasmodium species. This study demonstrates that the circumsporozoite protein of Plasmodium falciparum shows similarity with Plasmodium cynomolgi and Plasmodium knowlesi. The merozoite surface protein-1 of Plasmodium coatneyi forms a monophyletic group with Plasmodium knowlesi, demonstrating their close relationship and these two species also reveal similarity between the human malaria Plasmodium vivax. This Plasmodium phylogenetic arrangement is evidently crucial to identify shared derived characters as well as particular adaptation of plasmodium species from inside and between monophyletic groups.

Keywords

Circumsporozoite protein, Merozoite surface protein-1, Phylogenetic relationship, Plasmodium species.

Citation

Tripathi et al. Bioinformation 6(8): 320-323 (2011)
 

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.