Title

Modeling the mitochondrial dysfunction in neurogenerative diseases due to high H+ concentration 

Authors

Athanasios Alexiou¹*, John Rekkas², Panayiotis Vlamos¹ 

Affiliation

¹Department of Informatics, Ionian University, Plateia Tsirigoti 7, 49100 Corfu, Greece; ²School of Science & Technology, Hellenic Open University, 18 Plateia Aristotelous, 26335, Patra, Greece

Email

alexiou@ionio.gr; *Corresponding author

Phone

+30 210 9533296

Fax

+30 210 9533296

Article Type

Hypothesis

Date

Received April 28, 2011; Accepted May 07, 2011; Published May 26, 2011
 

Considering the latest researches, disruptions in the regulation of mitochondrial dynamics, low energy production, increased reactive oxygen species and mtDNA damage are relevant to human diseases, mainly in neurogenerative diseases and cancer. This article represents inner mitochondrial membrane as a natural superconductor giving also the corresponding mathematical model; nevertheless the creation of electric complexes into the inner mitochondrial membrane due to the unusual concentration of protons disrupts the normal flow of electrons and the production of ATP. Therefore, we propose the term ‘electric thromboses’ for the explanation of these inadequate electrons’ flow, presenting simultaneously a natural mechanism of this important and unique phenomenon. 

Keywords

Mitochondrial dynamics, neurogenerative diseases, electric thromboses, superconductivity
 

Citation

Alexiou et al. Bioinformation 6(5): 173-175 (2011)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.