Title

Glaucoma Database 

Authors

Rangachari K¹, Dhivya M¹, Eswari Pandaranayaka PJ¹, Prasanthi N², Sundaresan P², Krishnadas SR³, Krishnaswamy S¹*  

Affiliation

¹Bioinformatics Centre, Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, Tamilnadu, India; ²Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamilnadu, India; ³Glaucoma clinic, Aravind Medical Research Foundation, Madurai, Tamilnadu, India 

Email

krishna@mrna.tn.nic.in; *Corresponding author  

Article Type

Database

Date

Received September 02, 2010; Accepted December 12, 2010; Published February 07, 2011
 

Glaucoma, a complex heterogenous disease, is the leading cause for optic nerve-related blindness worldwide. Primary open angle glaucoma (POAG) is the most common subset and by the year 2020 it is estimated that approximately 60 million people will be affected. MYOC, OPTN, CYP1B1 and WDR36 are the important candidate genes. Nearly 4% of the glaucoma patients have mutation in any one of these genes. Mutation in any of these genes causes disease either directly or indirectly and the severity of the disease varies according to position of the genes. We have compiled all the related mutations and SNPs in the above genes and developed a database, to help access statistical and clinical information of particular mutation. This database is available online at http:bicmku.in:8081/glaucoma The database, constructed using SQL, contains data pertaining to the SNPs and mutation information involved in the above genes and relevant study data.  

Keywords

WD repeats 36 (WDR36), Optineurin (OPTN), Cytochrome P450 1 B chain (CYP1B1), Myocilin (MYOC) Single Nucleotide polymorphism (SNP), Structured Query language (SQL).

Availability

Citation

Rangachari et al. Bioinformation 5(9): 398-399 (2011)

Edited by

M Sakharkar

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.