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Title
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CFP: a web-server for constructing sequence-based protein conformational flexibility profiles |
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Authors |
Igor B. Kuznetsov1,*, Shalom Rackovsky2
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Affiliation
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1 Cancer Research Center, Department of Epidemiology and Biostatistics, University at Albany, One Discovery Drive, Rensselaer, NY 12144, USA; 2 Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
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Article Type
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Web Server | |
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Date
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Received September 20, 2009; Accepted October 14, 2009; Published October 19, 2009 | |
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Abstract |
Many proteins contain conformationally flexible segments that undergo significant changes in the backbone conformation or completely lack a well-defined conformation. Previously, we have developed the generalized local propensity (GLP), a quantitative sequence-based measure of the protein backbone flexibility. In this paper, we present the CFP (Conformational Flexibility Profile) web-server that constructs the GLP flexibility profile for a user-submitted sequence and uses this profile to identify segments with high backbone flexibility. The statistical significance of a flexible sequence segment is assessed using the discrete scan statistics based on the density of flexible residues observed in this segment.
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Keywords |
conformational variability, protein backbone, flexibility, local propensity, sequence | |
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Availability |
CFP is publicly available at http://cfp.rit.albany.edu | |
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Citation
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Kuznetsov & Rackovsky, Bioinformation 4 (5): 176-178 (2009) | |
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Edited by
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P. Kangueane
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ISSN
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0973-2063
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Publisher
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License
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This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |