Title

Structural prediction and analysis of VIH-related peptides from selected crustacean species

Authors

G. P. C. Nagaraju^1*, N. Siva Kumari^2$, G. L. V. Prasad^3$, B. Rajitha^1$, M. Meenu^4$, M. Sreenivasa Rao^5$, B. Reddya Naik^3$

Affiliation

¹Department of Biology, ⁴Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, FL-32816, USA; ²Department of Bioinformatics and ³Department of Zoology, Osmania University, Hyderabad, Andhra Pradesh, 500 007, India; 5Department of Chemistry, Chundi Ranganayakulu Post Graduate College, Chilakaluripet, Andhra Pradesh, 522 616, India

Email

gpcnraju@rediffmail.com

Article Type

Hypothesis

Date

Received March 24, 2009; Revised April 21, 2009; Accepted May 27, 2009; Published August 17, 2009

Abstract

The tentative elucidation of the 3D-structure of vitellogenesis inhibiting hormone (VIH) peptides is conversely underprivileged by difficulties in gaining enough peptide or protein, diffracting crystals, and numerous extra technical aspects. As a result, no structural information is available for VIH peptide sequences registered in the Genbank. In this situation, it is not surprising that predictive methods have achieved great interest. Here, in this study the molt-inhibiting hormone (MIH) of the kuruma prawn (Marsupenaeus japonicus) is used, to predict the structure of four VIHrelated peptides in the crustacean species. The high similarity of the 3D-structures and the calculated physiochemical characteristics of these peptides suggest a common fold for the entire family.

Keywords

Growth inhibiting hormone(GIH); Vitellogenin protein(VTG); Vitellogenesis inhibiting hormone (VIH); molt-inhibiting hormone (MIH); 3D-structure; homology model; shrimp or prawn.

Citation

Nagaraju et al, Bioinformation 4(1): 5-11 (2009)

Edited by

P. Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.